Difference between revisions of "Protein Interaction Resources"
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Revision as of 08:29, 19 May 2011
A collection of resources related to retrieving and working with protein interaction data.
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Name | Location | Notes and references | |
ID Mapping Service | |||
UniProt | http://www.uniprot.org/ | See the ID Mapping Tab | |
DAVID | http://david.abcc.ncifcrf.gov/ | DAVID | |
Ensemble BioMart | http://www.ensembl.org/index.html | See the BioMart Link | |
CyThesaurus | http://www.cytoscape.org/cgi-bin/moin.cgi/CyThesaurus_Plugin/ID_Mapping_Examples
http://www.cytoscape.org/cgi-bin/moin.cgi/CyThesaurus_Plugin/ |
A Cytoscape Plugin. Uses BridgeDb | |
Advanced Network Merge | http://www.cytoscape.org/cgi-bin/moin.cgi/Advanced_Network_Merge_and_ID_Mapping#API_Design | Cytoscape plugin. Uses BridgeDb | |
The Synergizer | http://llama.med.harvard.edu/synergizer/translate/ | Synergizer | |
BridgeDB | http://www.bridgedb.org./ | For programmatic access. http://www.biomedcentral.com/1471-2105/11/5/abstract | |
PICR | http://www.ebi.ac.uk/Tools/webservices/clients/picr | For programmatic access. | |
Primary Interaction Databases | |||
IMEx | http://imex.sourceforge.net | International Molecular Exchange Consortium | |
IMEx | http://imex.sourceforge.net/doc/imex-CurationManual.pdf | IMEx curation manual | |
BIND | http://bond.unleashedinformatics.com | Biomolecular Interaction Network Database (Inactive)4 | |
DIP | http://dip.doe-mbi.ucla.edu | Database of Interacting Proteins1 [1] | |
IntAct | http://www.ebi.ac.uk/intact | Interaction database at EBI1 [2, 3] | |
MINT | http://mint.bio.uniroma2.it/mint | Molecular Interaction Database2 [4] | |
MPACT | http://mips.gsf.de/genre/proj/mpact | Representation of Interaction Data at MIPS2 [5] | |
MatrixDB | http://matrixdb.ibcp.fr | Extracellular Matrix interactions Database2 | |
BioGRID | http://www.thebiogrid.org | General Repository for Interaction Datasets3 [6] | |
MPIDB | http://www.jcvi.org/mpidb | The Microbial Protein Interaction Database3 [7] | |
HPRD | http://www.hprd.org | Human Protein Reference Database [8, 9] | |
MPPI | http://mips.gsf.de/proj/ppi | The MIPS Mammalian Protein-Protein Interaction Database [10] | |
Pathguide | http://www.pathguide.org | A listing of multiple interaction and pathway databases [11] | |
B. Text-mining resources | |||
BioNLP | http://zope.bioinfo.cnio.es/bionlp_tools | A recent compilation of text-mining tools. [12] | |
iHOP | http://www.ihop-net.org/UniPub/iHOP | Information Hyperlinked Over Proteins [13] | |
EBIMed | http://www.ebi.ac.uk/Rebholz-srv/ebimed | PubMed abstract markup of for biological concepts. [14] | |
FACTA | http://text0.mib.man.ac.uk/software/facta | Finding Associated Concepts with Text Analysis [15] | |
PubGene | http://www.pubgene.org | Gene-centric retrieval of literature networks. [16] | |
InfoPubMed | https://www-tsujii.is.s.u-tokyo.ac.jp/info-pubmed | Interactions between genes in PubMed abstracts | |
Chillibot | http://www.chilibot.net | Relationships between genes, proteins or keywords in PubMed [17] | |
MedEvi | http://www.ebi.ac.uk/tc-test/textmining/medevi | Context-specific searches of PubMed abstracts. [18] | |
FABLE | http://fable.chop.edu | Fast Automated Biomedical Literature Extraction | |
PLN2L | http://zope.bioinfo.cnio.es/plan2l/plan2l.html | Text mining resource specific to Arabidopsis Thaliana PMID 19520768 | |
BioText | http://biosearch.berkeley.edu | Full-text search engine for open source articles. [19] | |
Reflect | http://reflect.ws | Web-browser plugin for markup of gene, protein and small-molecule names PMID 19513049 | |
C. Predicted Protein Interactions | |||
OPHID/I2D | http://ophid.utoronto.ca | Predicted Protein Interaction Database [20, 21] | |
InteroPorc | http://biodev.extra.cea.fr/interoporc | Predicted interactions based on orthologous protein clusters. [22] | |
FunCoup | http://funcoup.sbc.su.se | Networks of Functional Coupling | |
STRING | http://string.embl.de | Search Tool for Retrieval of Interacting Genes/Proteins [23] | |
Predictome | http://visant.bu.edu | Predicted interactions using a number of methods. [24, 25] | |
PRISM | http://prism.ccbb.ku.edu.tr/prism | Predicted protein interactions by structural mapping. [26] | |
InterPreTS | http://www.russell.embl.de/cgi-bin/interprets2 | Interaction Prediction through Tertiary Structure [27, 28] | |
3did | http://gatealoy.pcb.ub.es/3did | 3D interacting domains [29] | |
DIMA | http://mips.gsf.de/genre/proj/dima | Domain Interaction Map [30] | |
D. Interaction Confidence Scores and Consolidation | |||
DASMI | http://dasmi.bioinf.mpi-inf.mpg.de | Distributed Annotation Server for Molecular Interactions | |
PRINCESS | http://61.50.138.118/PICASSO/index.html | Protein Interaction Confidence Evaluation System with Multiple Sources [31] | |
iRefIndex | http://irefindex.uio.no | Interaction reference index. [32] | |
E. Integrated tools for visualization and analysis | |||
STRING | http://string.embl.de | Search Tool for Retrieval of Interacting Genes/Proteins [23] | |
STITCH | http://stitch.embl.de | Search Tool for Interactions of Chemicals with proteins [33] | |
DILIMOT | http://dilimot.embl.de | Discovery of Linear Motifs [34] | |
VisAnt | http://visant.bu.edu | Integrative Visual Analysis Tool for Biological Networks and Pathways [35] | |
Cytoscape | http://www.cytoscape.org | Application for visualizing and analyzing biological networks. [36] | |
PC | http://www.pathwaycommons.org/pc/ | Pathway Commons. Interaction and pathway database integration.5 | |
MiMI | http://mimi.ncibi.org | Michigan Molecular Interaction Database5 [37] | |
BioNetBuilder | http://err.bio.nyu.edu/cytoscape/bionetbuilder | Interaction data retrieval from multiple databases5. [38] | |
R | http://www.r-project.org | Free software environment for statistical computing and graphics. | |
Bioconductor | http://bioconductor.org | Open software for analysis of genomic data. [39] | |
FunCoup | http://funcoup.sbc.su.se | Networks of Functional Coupling | |
PPISpider | http://mips.gsf.de/proj/ppispider | Induction of protein interaction subgraphs from lists of proteins. | |
Torque | http://www.cs.tau.ac.il/~bnet/torque.html | Topology-Free Querying of Protein Interaction Networks PMID 19491310. | |
CPDB | http://cpdb.molgen.mpg.de | Consensus Path Database with overrepresentation analysis. [40] | |
SPIKE | http://www.cs.tau.ac.il/~spike | Signaling Pathway Integrated Knowledge Engine [41] | |
Complex Detection | |||
CME | http://www.kyb.tuebingen.mpg.de/~georgii/dme.htm | Dense module enumeration on a weighted graph PMID 19213739 | |
Commercial Resources | |||
GeneGo | http://www.genego.com | ||
Ingenuity | http://www.ingenuity.com | ||
Ariadne | http://www.ariadnegenomics.com | ||
Other related resources | |||
COSMIC | http://www.sanger.ac.uk/perl/genetics/CGP/cosmic | Catalogue of somatic mutations in cancer. |
1. Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU, Eisenberg D: The Database of Interacting Proteins: 2004 update. Nucleic Acids Res 2004, 32(Database issue):D449-451.
2. Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S, Vingron M, Roechert B, Roepstorff P, Valencia A et al: IntAct: an open source molecular interaction database. Nucleic Acids Res 2004, 32(Database issue):D452-455.
3. Kerrien S, Alam-Faruque Y, Aranda B, Bancarz I, Bridge A, Derow C, Dimmer E, Feuermann M, Friedrichsen A, Huntley R et al: IntAct--open source resource for molecular interaction data. Nucleic Acids Res 2007, 35(Database issue):D561-565.
4. Chatr-aryamontri A, Ceol A, Palazzi LM, Nardelli G, Schneider MV, Castagnoli L, Cesareni G: MINT: the Molecular INTeraction database. Nucleic Acids Res 2007, 35(Database issue):D572-574.
5. Guldener U, Munsterkotter M, Oesterheld M, Pagel P, Ruepp A, Mewes HW, Stumpflen V: MPact: the MIPS protein interaction resource on yeast. Nucleic Acids Res 2006, 34(Database issue):D436-441.
6. Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M: BioGRID: a general repository for interaction datasets. Nucleic Acids Res 2006, 34(Database issue):D535-539.
7. Goll J, Rajagopala SV, Shiau SC, Wu H, Lamb BT, Uetz P: MPIDB: the microbial protein interaction database. Bioinformatics 2008, 24(15):1743-1744.
8. Mishra GR, Suresh M, Kumaran K, Kannabiran N, Suresh S, Bala P, Shivakumar K, Anuradha N, Reddy R, Raghavan TM et al: Human protein reference database--2006 update. Nucleic Acids Res 2006, 34(Database issue):D411-414.
9. Peri S, Navarro JD, Amanchy R, Kristiansen TZ, Jonnalagadda CK, Surendranath V, Niranjan V, Muthusamy B, Gandhi TK, Gronborg M et al: Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res 2003, 13(10):2363-2371.
10. Pagel P, Kovac S, Oesterheld M, Brauner B, Dunger-Kaltenbach I, Frishman G, Montrone C, Mark P, Stumpflen V, Mewes HW et al: The MIPS mammalian protein-protein interaction database. Bioinformatics 2005, 21(6):832-834.
11. Bader GD, Cary MP, Sander C: Pathguide: a pathway resource list. Nucleic Acids Res 2006, 34(Database issue):D504-506.
12. Krallinger M, Valencia A, Hirschman L: Linking genes to literature: text mining, information extraction, and retrieval applications for biology. Genome Biology 2008, 9(Suppl 2).
13. Hoffmann R: Using the iHOP information resource to mine the biomedical literature on genes, proteins, and chemical compounds. Current protocols in bioinformatics / editoral board, Andreas D Baxevanis [et al 2007, Chapter 1:Unit1 16.
14. Rebholz-Schuhmann D, Kirsch H, Arregui M, Gaudan S, Riethoven M, Stoehr P: EBIMed--text crunching to gather facts for proteins from Medline. Bioinformatics 2007, 23(2):e237-244.
15. Tsuruoka Y, Tsujii J, Ananiadou S: FACTA: a text search engine for finding associated biomedical concepts. Bioinformatics 2008.
16. Jenssen TK, Laegreid A, Komorowski J, Hovig E: A literature network of human genes for high-throughput analysis of gene expression. Nat Genet 2001, 28(1):21-28.
17. Chen H, Sharp BM: Content-rich biological network constructed by mining PubMed abstracts. BMC Bioinformatics 2004, 5:147.
18. Kim JJ, Pezik P, Rebholz-Schuhmann D: MedEvi: retrieving textual evidence of relations between biomedical concepts from Medline. Bioinformatics 2008, 24(11):1410-1412.
19. Hearst MA, Divoli A, Guturu H, Ksikes A, Nakov P, Wooldridge MA, Ye J: BioText Search Engine: beyond abstract search. Bioinformatics 2007, 23(16):2196-2197.
20. Brown KR, Jurisica I: Online predicted human interaction database. Bioinformatics 2005, 21(9):2076-2082.
21. Brown KR, Jurisica I: Unequal evolutionary conservation of human protein interactions in interologous networks. Genome Biol 2007, 8(5):R95.
22. Michaut M, Kerrien S, Montecchi-Palazzi L, Chauvat F, Cassier-Chauvat C, Aude JC, Legrain P, Hermjakob H: InteroPORC: automated inference of highly conserved protein interaction networks. Bioinformatics 2008, 24(14):1625-1631.
23. von Mering C, Jensen LJ, Kuhn M, Chaffron S, Doerks T, Kruger B, Snel B, Bork P: STRING 7--recent developments in the integration and prediction of protein interactions. Nucleic Acids Res 2007, 35(Database issue):D358-362.
24. Mellor JC, Yanai I, Clodfelter KH, Mintseris J, DeLisi C: Predictome: a database of putative functional links between proteins. Nucleic Acids Res 2002, 30(1):306-309.
25. Hu Z, Ng DM, Yamada T, Chen C, Kawashima S, Mellor J, Linghu B, Kanehisa M, Stuart JM, DeLisi C: VisANT 3.0: new modules for pathway visualization, editing, prediction and construction. Nucleic Acids Res 2007, 35(Web Server issue):W625-632.
26. Keskin O, Nussinov R, Gursoy A: Prism: protein-protein interaction prediction by structural matching. Methods in molecular biology (Clifton, NJ 2008, 484:505-521.
27. Aloy P, Russell RB: InterPreTS: protein interaction prediction through tertiary structure. Bioinformatics 2003, 19(1):161-162.
28. Aloy P, Russell RB: Interrogating protein interaction networks through structural biology. Proc Natl Acad Sci U S A 2002, 99(9):5896-5901.
29. Stein A, Panjkovich A, Aloy P: 3did Update: domain-domain and peptide-mediated interactions of known 3D structure. Nucleic acids research 2008.
30. Pagel P, Oesterheld M, Tovstukhina O, Strack N, Stumpflen V, Frishman D: DIMA 2.0--predicted and known domain interactions. Nucleic Acids Res 2008, 36(Database issue):D651-655.
31. Li D, Liu W, Liu Z, Wang J, Liu Q, Zhu Y, He F: PRINCESS, a protein interaction confidence evaluation system with multiple data sources. Mol Cell Proteomics 2008, 7(6):1043-1052.
32. Razick S, Magklaras G, Donaldson IM: iRefIndex: A consolidated protein interaction database with provenance. BMC Bioinformatics 2008, 9(1):405.
33. Kuhn M, von Mering C, Campillos M, Jensen LJ, Bork P: STITCH: interaction networks of chemicals and proteins. Nucleic Acids Res 2008, 36(Database issue):D684-688.
34. Neduva V, Russell RB: DILIMOT: discovery of linear motifs in proteins. Nucleic Acids Res 2006, 34(Web Server issue):W350-355.
35. Hu Z, Snitkin ES, DeLisi C: VisANT: an integrative framework for networks in systems biology. Briefings in bioinformatics 2008, 9(4):317-325.
36. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T: Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 2003, 13(11):2498-2504.
37. Jayapandian M, Chapman A, Tarcea VG, Yu C, Elkiss A, Ianni A, Liu B, Nandi A, Santos C, Andrews P et al: Michigan Molecular Interactions (MiMI): putting the jigsaw puzzle together. Nucleic Acids Res 2007, 35(Database issue):D566-571.
38. Avila-Campillo I, Drew K, Lin J, Reiss DJ, Bonneau R: BioNetBuilder: automatic integration of biological networks. Bioinformatics 2007, 23(3):392-393.
39. Huber W, Carey VJ, Long L, Falcon S, Gentleman R: Graphs in molecular biology. BMC Bioinformatics 2007, 8 Suppl 6:S8.
40. Kamburov A, Wierling C, Lehrach H, Herwig R: ConsensusPathDB--a database for integrating human functional interaction networks. Nucleic Acids Res 2008.
41. Elkon R, Vesterman R, Amit N, Ulitsky I, Zohar I, Weisz M, Mass G, Orlev N, Sternberg G, Blekhman R et al: SPIKE--a database, visualization and analysis tool of cellular signaling pathways. BMC Bioinformatics 2008, 9:110.
Footnotes
1. Archival member of IMEx
2. Topical member of IMEx
3. Observing member of IMEx
4. Inactive member of IMEx
5. Available via a Cytoscape plugin
All iRefIndex Pages
Follow this link for a listing of all iRefIndex related pages (archived and current).