iRefIndex/PBR Notes

Preliminary BIND PSI-XML parsing results.

Results

Importing MITAB output from the iRefIndex 5.1 build and a build done using the BIND PSI-XML data, then comparing the interaction details for BIND, the following distributions are observed:

Interactions

			iRefIndex 5.1
	(Total)		(9811)
			3818
PSI-XML	(8916)	2923	5993

To summarise:

• Common interactions: 5993
• Interactions only in iRefIndex 5.1: 3818
• Interactions only in BIND PSI-XML: 2923

Interactors

			iRefIndex 5.1
	(Total)		(6896)
			2511
PSI-XML	(5324)	939	4385

To summarise:

• Common interactors: 4385
• Interactors only in iRefIndex 5.1: 2511
• Interactors only in BIND PSI-XML: 939

Queries

Common interactions:

select count(distinct mitab_sources.rigid)
from i5_mitab_sources
inner join mitab_sources
  on i5_mitab_sources.rigid = mitab_sources.rigid
  and i5_mitab_sources.name = mitab_sources.name
inner join i5_mitab_interactions
  on i5_mitab_sources.uidA = i5_mitab_interactions.uidA
  and i5_mitab_sources.uidB = i5_mitab_interactions.uidB
  and i5_mitab_sources.rigid = i5_mitab_interactions.rigid
where mitab_sources.name = 'bind'
  and taxA = 9606
  and taxB = 9606;

Interactions only in iRefIndex 5.1:

select count(distinct i5_mitab_sources.rigid)
from i5_mitab_sources
inner join i5_mitab_interactions
  on i5_mitab_sources.uidA = i5_mitab_interactions.uidA
  and i5_mitab_sources.uidB = i5_mitab_interactions.uidB
  and i5_mitab_sources.rigid = i5_mitab_interactions.rigid
where i5_mitab_sources.name = 'bind'
  and taxA = 9606
  and taxB = 9606
  and i5_mitab_sources.rigid not in (select rigid from mitab_sources where mitab_sources.name = 'bind');

Interactions only in BIND PSI-XML:

select count(distinct rigid)
from mitab_sources
where mitab_sources.name = 'bind'
  and rigid not in (
  select distinct i5_mitab_sources.rigid
  from i5_mitab_sources
  inner join i5_mitab_interactions
    on i5_mitab_sources.uidA = i5_mitab_interactions.uidA
    and i5_mitab_sources.uidB = i5_mitab_interactions.uidB
    and i5_mitab_sources.rigid = i5_mitab_interactions.rigid
  where i5_mitab_sources.name = 'bind'
    and taxA = 9606
    and taxB = 9606
  );

Common interactors:

select count(distinct X.uid)
from (
  select i5_mitab_sources.uidA as uid
  from i5_mitab_sources
  inner join i5_mitab_interactions
    on i5_mitab_sources.uidA = i5_mitab_interactions.uidA
  where name = 'bind' and taxA = 9606
  union
  select i5_mitab_sources.uidB as uid
  from i5_mitab_sources
  inner join i5_mitab_interactions
    on i5_mitab_sources.uidB = i5_mitab_interactions.uidB
  where name = 'bind' and taxB = 9606
  ) as X
inner join (
  select uidA as uid
  from mitab_sources
  where name = 'bind'
  union
  select uidB as uid
  from mitab_sources
  where name = 'bind'
  ) as Y
  on X.uid = Y.uid;

Interactors only in iRefIndex 5.1:

select count(distinct X.uid)
from (
  select i5_mitab_sources.uidA as uid
  from i5_mitab_sources
  inner join i5_mitab_interactions
    on i5_mitab_sources.uidA = i5_mitab_interactions.uidA
  where name = 'bind' and taxA = 9606
  union
  select i5_mitab_sources.uidB as uid
  from i5_mitab_sources
  inner join i5_mitab_interactions
    on i5_mitab_sources.uidB = i5_mitab_interactions.uidB
  where name = 'bind' and taxB = 9606
  ) as X
where X.uid not in (select uidA as uid from mitab_sources where name = 'bind' union select uidB as uid from mitab_sources where name = 'bind');

Interactors only in BIND PSI-XML:

select count(distinct X.uid)
from (select uidA as uid from mitab_sources where name = 'bind' union select uidB as uid from mitab_sources where name = 'bind') as X
where X.uid not in (
  select i5_mitab_sources.uidA as uid
  from i5_mitab_sources
  inner join i5_mitab_interactions
    on i5_mitab_sources.uidA = i5_mitab_interactions.uidA
  where name = 'bind' and taxA = 9606
  union
  select i5_mitab_sources.uidB as uid
  from i5_mitab_sources
  inner join i5_mitab_interactions
    on i5_mitab_sources.uidB = i5_mitab_interactions.uidB
  where name = 'bind' and taxB = 9606
  );

Other Stuff

This is what I did for the unnecessary "new BIND vs. other sources" experiment...

Downloaded the following:

• BioGrid
• CORUM
• DIP
• HPRD
• Intact
• MINT
• MIPS (MPPI)
• OPHID

Modified the following:

• BioGrid - removed all but human data

Parsed all sources mentioned above.

Removed all non-9606 records.

Did ROG assignment and so on.

Made the reports.