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| + | __NOTOC__ |
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| − | {|class="wikitable" style="text-align:right" border="0" cellpadding="10" | + | iRefIndex provides an index of protein interactions available in a number of primary interaction databases including BIND, BioGRID, CORUM, DIP, HPRD, InnateDB, IntAct, MatrixDB, MINT, MPact, MPIDB, MPPI, Reactome, VirHostnet, and QuickGO. |
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| + | {|class="wikitable" style="text-align:left; clear: left" border="0" cellpadding="10" |
| − | Image:iRefIndex_logo.png|180x180px
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| − | default [[iRefIndex]]
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| − | </imagemap>
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| − | default [[iRefIndex_Videos]]
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| − | </imagemap>
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| − | [http://irefindex.uio.no/wiki/iRefIndex_Videos Take the video tour]
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| − | Image:IMEx_logo_webmedium.jpg|180x180px
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| − | default [http://www.psimex.org]
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| − | </imagemap>
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| − | |iRefIndex is a PSIMex partner:
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| − | http://www.psimex.org
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| − | http://www.imexconsortium.org.
| + | <!--Download row row--> |
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| − | |}
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| − | </div>
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| | + | <!--Download image--> |
| | + | |<imagemap> |
| | + | Image:Document-save-80x80.png |
| | + | default [[README_MITAB2.6_for_iRefIndex]] |
| | + | desc none |
| | + | </imagemap> |
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| | + | <!--Download link and text--> |
| | + | | style="vertical-align: top" | |
| | + | === [[README_MITAB2.6_for_iRefIndex|Download]] === |
| | + | Download version 20.0 of the iRefIndex in PSI-MITAB tab-delimited format. |
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| | | | |
| − | == A reference index for protein interaction data ==
| + | <!--More about iRefIndex row--> |
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| − | iRefIndex provides an index of protein interactions available in a number of primary interaction databases including [http://bond.unleashedinformatics.com/ BIND], [http://www.thebiogrid.org/ BioGRID], [http://mips.gsf.de/genre/proj/corum/index.html CORUM], [http://dip.doe-mbi.ucla.edu/ DIP], [http://www.hprd.org/ HPRD], [http://www.ebi.ac.uk/intact/site/index.jsf IntAct], [http://mint.bio.uniroma2.it/mint/Welcome.do MINT], [http://mips.gsf.de/genre/proj/mpact MPact], [http://mips.gsf.de/proj/ppi/ MPPI] and [http://ophid.utoronto.ca/ OPHID]. This index includes multiple interaction types including physical and genetic (mapped to their corresponding protein products) as determined by a multitude of methods. This index allows the user to search for a protein and retrieve a non-redundant list of interactors for that protein. | + | <!-- iRefIndex logo --> |
| | + | |<imagemap> |
| | + | Image:iRefIndex_logo.png|80x80px |
| | + | default [[ iRefIndex more ]] |
| | + | desc none |
| | + | </imagemap> |
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| − | iRefIndex assigns a global unique identifier (rigid) which looks like 'tjWXXjgPyHyT2J6EwED8zK2x18U' to identify interactions that are identical (according to the sequence and taxon ids of the interactors). iRefIndex also assigns similar looking keys to protein interactors. These keys are global meaning they can be generated by anyone using the method described in the paper. This method allows users to integrate their own data with the iRefIndex in a way that ensures proteins with the exact same sequence will be represented only once. | + | <!-- iRefIndex more link and text --> |
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| − | '''Publications'''
| + | === [[ iRefIndex more | More about iRefIndex ]] === |
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| − | iRefIndex: a consolidated protein interaction database with provenance. 2008 [http://www.biomedcentral.com/1471-2105/9/405/abstract Available here]. | + | More ways to access iRefIndex, documentation, release notes, citations and references, technical details, mailing list, contact and license. |
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| − | iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence. 2010
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| − | [http://database.oxfordjournals.org/content/2010/baq023.long Available here]
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| − | Literature curation of protein interactions: measuring agreement across major public databases. 2010
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| − | [http://database.oxfordjournals.org/content/2010/baq026 Available here]
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| | + | <!--More about Donaldson Research row--> |
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| − | '''iRefIndex is a PSIMex partner'''
| + | <!-- donaldson research logo --> |
| | + | |<imagemap> |
| | + | Image:donaldson_research_logo.png|80x80px |
| | + | default [[ Donaldson Research ]] |
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| | + | </imagemap> |
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| − | http://www.psimex.org
| + | <!-- iRefIndex more link and text --> |
| | + | | style="vertical-align: top" | |
| | + | === [[ Donaldson Research | More about Donaldson Research ]] === |
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| − | http://www.imexconsortium.org.
| + | Support for updates to and use of iRefIndex can be provided by Donaldson Research. |
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| − | ----
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| − | == Long term goals of the iRefIndex project ==
| + | <!--More about VIB row--> |
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| − | We believe that protein interaction data hold incredible potential for biomedical research. Presently, these data are collected and archived by multiple groups around the world and the number of groups taking part in this work is growing rather than diminishing.
| + | <!-- VIB logo --> |
| | + | |<imagemap> |
| | + | Image:donaldson_research_logo.png|80x80px |
| | + | default [[ Donaldson Research ]] |
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| | + | </imagemap> |
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| − | As such, it is important that these databases have the means to effectively exchange and compare data and that they are curating and representing data using similar standards in order to make their data accessible and allow effective use.
| + | <!-- VIB more link and text --> |
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| − | To this end, the iRefIndex project has three long term objectives:
| + | === [http://irefindex.vib.be More about the VIB Bioinformatics Core] === |
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| − | ;1) to facilitate exchange of interaction data between interaction databases.
| + | The iRefIndex site is now hosted at the VIB Bioinformatics Core including [http://www.ebi.ac.uk/Tools/webservices/psicquic/registry/registry?action=STATUS PSICQUIC webservices] that can be accessed [https://irefindex.vib.be/webservices here] using either SOAP or REST. |
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| − | :The iRefIndex paper describes a method for assigning unique and global identifiers to protein interactors, interactions and complexes. This method is independent of the iRefIndex resource and may be used by anyone to facilitate exchange and consolidation of data.
| + | |} |
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| − | ;2) to consolidate interaction data from multiple sources.
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| − |
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| − | :The method has been used by to index interaction records from multiple sources. The resulting iRefIndex may be used search for the existence of interaction data for any protein regardless of the original resource. Nine interaction databases have been incorporated so far, others will follow.
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| − | ;3) to provide feedback to source interaction databases.
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| − |
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| − | :During the process of data consolidation, iRefIndex uses a sophisticated method to keep track of potential problems with source records such as outdated or unfound protein identifiers or incorrectly assigned taxonomy identifiers. These data are provided as feedback files to source interaction databases for correction, clarification or improvements to our own system. This process will help to harmonize data representation and improve the overall quality of interaction records for all source databases. This process will also help source databases to exchange data with one another.
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| − | ==iRefIndex availability via download ==
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| − | All iRefIndex data is provided as a tab-delimited text file in PSI-MITAB format.
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| − | Data is available via anonymous FTP at:
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| − | ftp://ftp.no.embnet.org/irefindex/data
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| − | Username: <tt>ftp</tt>
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| − | Password: enter <tt>anonymous</tt> or your e-mail address
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| − |
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| − | {{Note|
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| − | iRefIndex data is now provided as a tab-delimited text file in PSI-MITAB 2.6 format. The format is described at:
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| − | }}
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| − | http://irefindex.uio.no/wiki/README_MITAB2.6_for_iRefIndex_8.0
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| − | iRefIndex data is provided as a single file or in a number of data sets specific to the organism in which the interaction occurs. See the above link for details.
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| − |
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| − | ==Source data for the current build ==
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| − |
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| − | is described at
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| − | http://irefindex.uio.no/wiki/Sources_iRefIndex_8.0
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| | ---- | | ---- |
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| − | ==iRefWeb: Data availability via web interface == | + | == Contact == |
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| − | iRefWeb provides a searchable web interface to the iRefIndex. iRefWeb also provides visualization of statistics related to iRefIndex and allows users to compare annotation of the same publication by multiple interaction databases.
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| − | http://wodaklab.org/iRefWeb/
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| − | Please see the upper right hand corner of this iRefWeb front page for the version of iRefIndex that iRefWeb is using.
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| − | The iRefWeb paper is available
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| − | [http://database.oxfordjournals.org/content/2010/baq023.long here].
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| − | | |
| − | ==iRefScape: Data availability via Cytoscape ==
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| − | Plugins for two versions of Cytoscape (http://cytoscape.org) have been released:
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| − | '''Cytoscape 2.7 users:'''
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| − | Install iRefScape 0.90 beta from the Plugins menu.
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| − | This version is not backwards compatible with Cytoscape 2.6.3.
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| − | Linux users with Java 1.6 (not 1.5) will not be able to install the plugin using the Plugin manager (instead, install manually – see links below)
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| − | Details on plugin installation and use are available at: [[README_Cytoscape_plugin_0.9x]]
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| − | '''Cytoscape 2.6.3 users:'''
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| − | Install iRefScape 0.89 beta from the Plugins menu
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| − | This will be the last iRefScape that supports Cytoscape 2.6.3
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| − | Details on plugin installation and use are available at: [[README_Cytoscape_plugin_0.8x]]
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| − |
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| − | Sign up for the Google Groups email list (below) to be informed of the official release and updates.
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| − | ==PSICQUIC: Data availability via Web services ==
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| − | A beta version of web-services is available for testing purposes. These services are based on a template from the IntAct [http://www.ebi.ac.uk/intact] group at EBI. Please see the contact information and Google Groups info below if you plan to use these services or would like to know when they are officially released.
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| − | [[README PSICQUIC web services for iRefIndex]]
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| − | iRefIndex PSICQUIC web services are now running on release 8.0 of iRefIndex
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| − | == Feedback files ==
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| − | We provide feedback to source databases about our data integration process. These files are described here :
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| − | [[README_iRefIndex_Feedback_8.0]]
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| | + | If you have comments, questions or would like to be added to a list receiving news of updates, please write to us at: |
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| | + | VIB Bioinformatics core [mailto:bits@vib.be] or Ian Donaldson [mailto:ian@donaldsonresearch.com email me] |
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| | ---- | | ---- |
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| − | == License ==
| + | [[Category:iRefIndex]] |
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| − | Data released on the public FTP site is released under Creative Commons Attribution License http://creativecommons.org/licenses/by/2.5/
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| − | | |
| − | == Disclaimer ==
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| − | | |
| − | Data is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
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| − | | |
| − | ----
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| − | == Statistics ==
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| − | Statistics for the iRefIndex include a breakdown of interactors and interactions from each data source.
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| − | For statistics on full public dataset (distributed on the FTP site contains) please refer to:
| + | <!-- |
| − | http://irefindex.uio.no/wiki/Statistics_iRefIndex_8.0 <br>
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| | | | |
| | | | |
| − | ----
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| | | | |
| − | == Credits == | + | |<html> |
| | + | <form action="https://www.paypal.com/cgi-bin/webscr" method="post" target="_top"> |
| | + | <input type="hidden" name="cmd" value="_s-xclick"> |
| | + | <input type="hidden" name="hosted_button_id" value="EE635XFGX4E8L"> |
| | + | <input type="image" src="https://www.paypalobjects.com/en_US/NO/i/btn/btn_donateCC_LG.gif" border="0" name="submit" alt="PayPal - The safer, easier way to pay online!"> |
| | + | <img alt="" border="0" src="https://www.paypalobjects.com/en_US/i/scr/pixel.gif" width="1" height="1"> |
| | + | </form> |
| | + | </html> |
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| − | The iRefIndex was developed at the Biotechnology Centre of Oslo, University of Oslo in the Donaldson lab by Sabry Razick and Ian Donaldson. Paul Boddie provides ongoing maintenance and development support. George Magklaras provides systems engineer support and EMBNet Norway provided hardware support.
| + | | style="vertical-align: top" | |
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| − | ----
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| − | == Citation == | + | === [[ Donations | Donations welcome ]] === |
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| − | iRefIndex has been published and is available [http://www.biomedcentral.com/1471-2105/9/405/abstract here]. If you use iRefIndex, please cite: | + | About iRefIndex costs and donating. |
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| − | Razick S, Magklaras G, Donaldson IM: '''iRefIndex: A consolidated protein interaction database with provenance.''' BMC Bioinformatics. 2008. 9(1):405 PMID 18823568.
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| − | Please also cite the source databases described below. iRefIndex consolidates protein interaction data from...
| + | --> |
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| − | * BIND [[#ref1|[1]]], [[#ref2|[2]]],
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| − | * BioGRID [[#ref3|[3]]],
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| − | * CORUM [[#ref14|[14]]],
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| − | * DIP [[#ref4|[4]]],
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| − | * HPRD [[#ref5|[5]]], [[#ref6|[6]]],
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| − | * IntAct [[#ref7|[7]]], [[#ref8|[8]]],
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| − | * MINT [[#ref9|[9]]],
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| − | * MPact [[#ref10|[10]]],
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| − | * MPPI [[#ref11|[11]]] and
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| − | * OPHID [[#ref12|[12]]].
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| − | | |
| − | iRefIndex uses SEGUID based identifiers to group proteins into redundant groups. The SEGUID algorithm and database are
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| − | described in [[#ref13|[13]]].
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| − | | |
| − | ---- | |
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| − | == References ==
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| − | | |
| − | <div id="ref1">1. Bader GD, Betel D, Hogue CW: '''BIND: the Biomolecular Interaction Network Database'''. Nucleic Acids Res 2003, 31(1):248-250.</div>
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| − | <div id="ref2">2. Alfarano C, Andrade CE, Anthony K, Bahroos N, Bajec M, Bantoft K, Betel D, Bobechko B, Boutilier K, Burgess E et al: '''The Biomolecular Interaction Network Database and related tools 2005 update'''. Nucleic Acids Res 2005, 33(Database issue):D418-424.</div>
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| − | <div id="ref3">3. Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M: '''BioGRID: a general repository for interaction datasets'''. Nucleic Acids Res 2006, 34(Database issue):D535-539.</div>
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| − | <div id="ref4">4. Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU, Eisenberg D: '''The Database of Interacting Proteins: 2004 update'''. Nucleic Acids Res 2004, 32(Database issue):D449-451.</div>
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| − | <div id="ref5">5. Peri S, Navarro JD, Amanchy R, Kristiansen TZ, Jonnalagadda CK, Surendranath V, Niranjan V, Muthusamy B, Gandhi TK, Gronborg M et al: '''Development of human protein reference database as an initial platform for approaching systems biology in humans'''. Genome Res 2003, 13(10):2363-2371.</div>
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| − | <div id="ref6">6. Mishra GR, Suresh M, Kumaran K, Kannabiran N, Suresh S, Bala P, Shivakumar K, Anuradha N, Reddy R, Raghavan TM et al: '''Human protein reference database--2006 update'''. Nucleic Acids Res 2006, 34(Database issue):D411-414.</div>
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| − | <div id="ref7">7. Hermjakob H, Montecchi-Palazzi L, Lewington C, Mudali S, Kerrien S, Orchard S, Vingron M, Roechert B, Roepstorff P, Valencia A et al: '''IntAct: an open source molecular interaction database'''. Nucleic Acids Res 2004, 32(Database issue):D452-455.</div>
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| − | <div id="ref8">8. Kerrien S, Alam-Faruque Y, Aranda B, Bancarz I, Bridge A, Derow C, Dimmer E, Feuermann M, Friedrichsen A, Huntley R et al: '''IntAct--open source resource for molecular interaction data'''. Nucleic Acids Res 2007, 35(Database issue):D561-565.</div>
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| − | <div id="ref9">9. Chatr-aryamontri A, Ceol A, Palazzi LM, Nardelli G, Schneider MV, Castagnoli L, Cesareni G: '''MINT: the Molecular INTeraction database'''. Nucleic Acids Res 2007, 35(Database issue):D572-574.</div>
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| − | <div id="ref10">10. Guldener U, Munsterkotter M, Oesterheld M, Pagel P, Ruepp A, Mewes HW, Stumpflen V: '''MPact: the MIPS protein interaction resource on yeast'''. Nucleic Acids Res 2006, 34(Database issue):D436-441.</div>
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| − | <div id="ref11">11. Pagel P, Kovac S, Oesterheld M, Brauner B, Dunger-Kaltenbach I, Frishman G, Montrone C, Mark P, Stumpflen V, Mewes HW et al: '''The MIPS mammalian protein-protein interaction database'''. Bioinformatics 2005, 21(6):832-834.</div>
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| − | <div id="ref12">12. Brown KR, Jurisica I: '''Online predicted human interaction database'''. Bioinformatics 2005, 21(9):2076-2082.</div>
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| − | <div id="ref13">13. Babnigg G, Giometti CS: '''A database of unique protein sequence identifiers for proteome studies'''. Proteomics 2006, 6(16):4514-4522</div>
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| − | <div id="ref14">14. Andreas Ruepp, Barbara Brauner, Irmtraud Dunger-Kaltenbach, Goar Frishman, Corinna Montrone, Michael Stransky, Brigitte Waegele, Thorsten Schmidt, Octave Noubibou Doudieu, Volker Stümpflen, H. Werner Mewes: '''CORUM: the Comprehensive Resource of Mammalian Protein Complexes'''. Nucleic Acids Res. 2008 Jan 1; 36(Database issue):D
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| − | ==Citations==
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| − | Some studies that have made use of the iRefIndex are listed on the [iRefIndex Citations] page.
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| − | == Other Resources ==
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| − | A collection of resources related to finding and working with protein interaction data: [[Protein Interaction Resources]].
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| − | | |
| − | == Contact ==
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| − | | |
| − | Suggestions, requests and comments are welcome. Please email
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| − | ian.donaldson at biotek.uio.no.
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| − | | |
| − | Visiting and mail address info is [http://www.biotek.uio.no/research/donaldson_group/ here].
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| − | | |
| − | == iRefIndex Google Group ==
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| − | | |
| − | Join the iRefIndex Google group and receive announcement emails and discuss issues related to iRefIndex.
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| − | Sign up at [http://groups.google.com/group/irefindex?hl=en irefindex google group].
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| − | == All iRefIndex Pages ==
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| − | | |
| − | Follow this link for a listing of all iRefIndex related pages (archived and current).
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| − | [[Category:iRefIndex]]
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