Difference between revisions of "Bioinformatics course"
Line 81: | Line 81: | ||
[http://bioinformatics.uio.no/wiki/Image:Exploratory_data_analysis_extra_materials.zip Extra material] | [http://bioinformatics.uio.no/wiki/Image:Exploratory_data_analysis_extra_materials.zip Extra material] | ||
|- | |- | ||
− | |11:15-13.00|| Antonio Mora begin_of_the_skype_highlighting end_of_the_skype_highlighting || http://donaldson.uio.no || | + | |11:15-13.00|| Antonio Mora begin_of_the_skype_highlighting end_of_the_skype_highlighting begin_of_the_skype_highlighting end_of_the_skype_highlighting || http://donaldson.uio.no || |
[http://biotin.uio.no/wikifiles//images/d/de/Intro_R_presentation.pdf Introduction to R - Presentation] | [http://biotin.uio.no/wikifiles//images/d/de/Intro_R_presentation.pdf Introduction to R - Presentation] | ||
|- | |- | ||
Line 114: | Line 114: | ||
[http://bioinformatics.uio.no/wikifiles//images/8/81/Searching_sequence_databases.pdf Searching sequence databases] | [http://bioinformatics.uio.no/wikifiles//images/8/81/Searching_sequence_databases.pdf Searching sequence databases] | ||
|- | |- | ||
− | |11:15-13.00|| | + | |11:15-13.00|| Geir K. Sandve || http://www.uio.no/sok?la=en&person=geirksa || [http://bioinformatics.uio.no/wikifiles//images/d/d5/Motif_discovery.pdf Motif scanning and discovery in DNA] |
− | [http://bioinformatics.uio.no/wikifiles//images/ | ||
|- | |- | ||
− | |14.15-16.00|| | + | |14.15-16.00|| || || |
− | |||
|- | |- | ||
|style="background:SteelBlue; color:white" colspan="4" align="center"| Day 5 - Friday September 10 | |style="background:SteelBlue; color:white" colspan="4" align="center"| Day 5 - Friday September 10 |
Revision as of 12:51, 14 June 2010
Contents
Bioinformatics for molecular biology - Fall 2010
Description
The aim of the course is to introduce students to bioinformatics resources and tools for molecular biology research by having some of the best researchers in Norway to talk about their field in general and then present their own work. Students are encouraged to bring a lap-top; we will be set up for in-course demonstrations as well as practical lab exercises. The course is intended for biology students or computer science/math students. No prior background in bioinformatics or computer science is required.
The course is jointly delivered by the Biotechnology Centre of Oslo, the Department of Molecular Biosciences (IMBV), the Department of Informatics (IFI) and the Norwegian University of Life Sciences. This course is one of the Ph.D. School courses offered by the Biotechnology Centre of Oslo (http://www.biotek.uio.no/ny-web/events/). The UiO page for this course is http://www.uio.no/studier/emner/matnat/molbio/MBV-INF4410/.
Registration will be open in May of 2010. Check back here for details
MBV-INF 4410 (M.Sc. level course code)10.0 study points
MBV-INF 9410 (Ph.D. level course code) 10.0 study points
MBV-INF 9410A (Ph.D. level course code) 8.0 study points
The course consists of two weeks of lectures, a final take-home exam (one week) and an essay (M.Sc. level 10 pages and Ph.D. level 20 pages to be completed by end of October).
Ph.D. level students may opt to take the course without the essay for only 8 study points.
Please bookmark this page. All future changes or announcements for the 2010 course will be posted to this page.
Information: ragni.indahl@biotek.uio.no (about course administration) ian.donaldson@biotek.uio.no (about course content) Registration: torill.rortveit@imbv.uio.no
Dates and times
The course will occur September 6th to 17th.
Each day will consist of three time slots for lectures and/or practical labs between 9 AM and 4 PM.
Place
Forskningsparken
Directions to Forsknings parken can be found at http://www.biotek.uio.no/map.html
Mondays to Friday morning: Room 10 (one level down from the main entrance) The room is booked each day from 09:00 to 16:00 EXCEPT Fridays when the room must be vacated from 12 to 13:30.
Exceptions: none so far
Lunch is on your own between 1:00 PM and 2:15 PM. Please completely vacate the room during these lunch times.
Programme
Please note: The schedule displayed below is based on last years course (see http://donaldson.uio.no/wiki/Bioinformatics_for_molecular_biology_2009). Ongoing changes will be made to this page as we organize speakers over the next few months. Requests and suggestions are welcome.
Time | Speaker | Contact | Details and suggested readings |
---|---|---|---|
Day 1 - Monday September 6 | |||
9.00-9.15 | Ian Donaldson | http://donaldson.uio.no | Introduction |
9.15-11.00 | Anja Bråthen Kristoffersen (TBC) | http://heim.ifi.uio.no/~anjab/ | |
11:15-13.00 | Antonio Mora begin_of_the_skype_highlighting end_of_the_skype_highlighting begin_of_the_skype_highlighting end_of_the_skype_highlighting | http://donaldson.uio.no | |
14.15-16.00 | Antonio Mora | http://donaldson.uio.no | |
Day 2 - Tuesday September 7 | |||
9.15-11.00 | Ole Christian Lingjærde | http://heim.ifi.uio.no/~ole/ | |
11:15-13.00 | Einar A. Rødland | http://folk.uio.no/einarro/ | |
14.15-16.00 | |||
Day 3 -Wednesday September 8 | |||
9.15-11.00 | Leonardo Meza-Zepeda | Dept. of Tumor Biology, Rikshospitalet-Radiumhospitalet Medical Center | |
11:15-13.00 | Ståle Nygård | http://core.rr-research.no/index.php?section=22 | |
14.15-16.00 | Ståle Nygård | R Microarray data analysis lab | |
Day 4 - Thursday September 9 | |||
9.15-11.00 | Torbjørn Rognes | http://www.rr-research.no/rognes/ | |
11:15-13.00 | Geir K. Sandve | http://www.uio.no/sok?la=en&person=geirksa | Motif scanning and discovery in DNA |
14.15-16.00 | |||
Day 5 - Friday September 10 | |||
9.15-11.00 | Dave W. Ussery | http://www.cbs.dtu.dk/staff/dave/ |
Comparative genomics Methods to compare genomes Pan-genomics and metagenomics |
11:15-13.00 | Karin Lagesen | http://folk.uio.no/karinlag/ | Sequence lab |
14.15-16.00 | Geir K. Sandve | http://www.uio.no/sok?la=en&person=geirksa |
Sequence lab |
Day 6 - Monday September 13 | |||
9.15-11.00 | Jon K. Laerdahl | ||
11:15-13.00 | Jon K. Laerdahl |
Structural bioinformatics tools, predictors, and 3D modeling | |
14.15-16.00 | Jon K. Laerdahl | Structural tutorials and exercises | |
Day 7 - Tuesday September 14 | |||
9.15-11.00 | |||
11:15-13.00 | |||
14.15-16.00 | |||
Day 8 - Wednesday September 15 | |||
9.15-11.00 | Ian Donaldson | http://donaldson.uio.no | |
11:15-13.00 | Ian Donaldson | http://donaldson.uio.no | |
14.15-16.00 | Antonio Mora, Sabry Razick, Paul Boddie | http://donaldson.uio.no | Interaction lab
Install http://cytoscape.org and http://irefindex.uio.no/wiki/README_Cytoscape_plugin_0.5x |
Day 8 - Thursday September 16 | |||
9.15-10.00 | Erik Plahte | http://www.cigene.no/people.html | |
10.15-11.00 | Arne Gjuvsland | http://www.cigene.no/people.html |
Causally cohesive genotype-phenotype modelling - systems biology meets genetics |
11.15-12.00 | Jon Olav Vik | http://www.cigene.no/people.html | |
12:15-13.00 | Harald Martens | http://www.cigene.no/people.html |
Bio-chemometrics_and_multivariate_data_modelling_in_systems_biology |
13:00-14.15 | Lunch | ||
14.15-15.00 | Achim Kohler | http://www.cigene.no/people.html | |
15.15-16.00 | Solve Sæbø | http://www.umb.no/ikbm/ansatte/solve.sabo | |
Day 9 - Friday September 17 | |||
9:00-11:00 | George Magklaras | http://www.no.embnet.org/ | |
11:15-13.00 | Kamran Shalchian-Tabrizi | http://www.bioportal.uio.no | |
13:00-14:00 | Lunch | ||
14.15-16.00 | Ian Donaldson | Course review |
Written assignment
Please note: The displayed essay topics are from last year as an example. The 2010 course assignments will be different.
Students enrolled in MBV-INF 4410 must complete a written assignment as part of the course requirements.
The assignment is due by October 27th. It should be emailed to ian.donaldson at biotek.uio.no preferably as a PDF document (Microsoft Word or OpenOffice is also acceptable). The assignment is to be between 1000 to 2000 words and no more than 10 pages. Topics include:
1) write an explanation of three or more methods that were covered in the course. These should be simple explanations aimed at someone approaching the topic for the first time. Your explanation may include derivations of equations (if they are clearly explained), figures or tables. Use examples. Describe how the concept can be applied to a problem in biological research and what limitations the method has. List any resources you use as well as references to additional material that a student might use if they want to follow up on the topic further. Please indicate whether your material may be used on the course's wiki page.
2) describe how you would use two or more of the methods covered in the course in your own research. Your proposal may include figures or tables. Give a short introduction to your problem area, clearly state your hypothesis and how you think it might be addressed by each of the methods. Provide justifications for your proposal as well as expected outcome. Describe potential risks (say, the method provides no meaningful results) and what you would do to mitigate this risk. List any resources you use.
3) you may define your own alternative topic. Please send an email to ian.donaldson at biotek.uio.no to have your topic approved first.
Exam
Please note: The exam for this course will be a one week take home exam.
Bioinformatics links relevant to the course
Name | URL | Description | |
---|---|---|---|
Day 1 - Statistics | |||
StatSoft textbook | http://statsoft.com/textbook/stathome.html | Good overview of methods and concepts | |
SAS manuals | http://support.sas.com/onlinedoc/913/ | Thorough overview of analysis procedures found in SAS | |
GraphPad | http://graphpad.com/help/prism5/prism5help.html?usingstatistical_analyses_step_by_s.htm | See the GraphPad statistical guide for easy introductions to many concepts in statistics | |
Day 2 - Statistics | |||
R | http://cran.r-project.org/ | The Comprehensive R Archive Network | |
Learning R | http://www.ploscompbiol.org/article/info:doi%2F10.1371%2Fjournal.pcbi.1000482 | A Quick Guide to Teaching R Programming to Computational Biology Students | |
EMBNet Microarray course | http://vit-embnet.unil.ch/CoursEMBnet/Arrays06/Material.html | An online course with R/Bioconductor example tutorials | |
EMBNet tutorials | http://www.ch.embnet.org/pages/courses2.html | Other helpful tutorials with R examples related to biostatistics | |
Day 3 - Microarrays | |||
NMC | http://www.mikromatrise.no/ | Norwegian Microarray Consrtium | |
MACF | http://core.rr-research.no/ | UiO MicroArray Facility | |
Bioinformatics core facility | http://core.rr-research.no/index.php?section=3 | The Bioinformatics Core Facility established at Rikshospitalet-Radiumhospitalet (RR) will provide its users at RR and the University of Oslo with a range of services within bioinformatics, including analysis of DNA and protein sequences, analysis of microarray data, protein structure analysis and access to useful databases and web services | |
Day 4 - 5 Sequence | |||
RSAT | RSAT | A collection of several motif-related tools | |
ConTra | ConTra | A more user-friendly tool for matching a collection of Position Weighted Matrices against promoter sequences across species | |
Day 6 - | |||
Day 7 - | |||
Required files | [Sample network[1]] [Node atributes[2]] | Please download these and uncompress before using | |
Cytoscape | http://www.cytoscape.org/ | Cytoscape home page | |
Cytoscape | http://cytoscape.org/cgi-bin/moin.cgi/Presentations | Tutorial on Cytoscape | |
iRefIndex Cytoscape plugin | http://irefindex.uio.no/wiki/README_Cytoscape_plugin_0.5x | iRefIndex installation | |
iRefIndex | http://irefindex.uio.no | iRefIndex wiki | |
iRefIndex publication | http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18823568 | Full details of iRefIndex | |
DAVID | http://www.nature.com/nprot/journal/v4/n1/pdf/nprot.2008.211.pdf | Nature Protocols paper | |
GSEA | http://www.broadinstitute.org/gsea/doc/subramanian_tamayo_gsea_pnas.pdf | PNAS paper | |
GSEA | http://www.broadinstitute.org/gsea | Gene Set Enrichment Analysis application |
Bioinformatics Mailing Lists
If you are interested in being informed of future courses, talks and new related to bioinformatics in the Oslo region, then consider signing up for the cbo mailing list.
https://sympa.uio.no/usit.uio.no/info/cbo-all
You might also consider the Norwegian-wide bioinformatics email list. You can sign up at
http://mailman.uib.no/listinfo/bioinfo.users.
Both lists are run by members of the Norwegian Bioinformatics Platform.