Statistics iRefIndex 3.0

Interactions

BIND	62831
BIOGRID	20701	155527
DIP	0	0	0
HPRD	0	0	0	0
INTACT	24372	25772	0	0	110545
MINT	22406	32690	0	0	42208	73729
MPACT	0	0	0	0	0	0	0
MPPI	385	26	0	0	88	106	0	825
OPHID	2201	1309	0	0	7177	7141	0	183	47303
CORUM	0	0	0	0	0	0	0	0	0	0
	BIND	BIOGRID	DIP	HPRD	INTACT	MINT	MPACT	MPPI	OPHID	CORUM
	(30966)	(112572)	(0)	(0)	(57940)	(16196)	(0)	(298)	(35791)	(0)

Interactors

BIND	40738
BIOGRID	14397	27164
DIP	0	0	0
HPRD	0	0	0	0
INTACT	18077	16676	0	0	41370
MINT	16294	14898	0	0	22877	28043
MPACT	0	0	0	0	0	0	0
MPPI	669	209	0	0	575	551	0	858
OPHID	3210	2261	0	0	5720	4807	0	422	9631
CORUM	0	0	0	0	0	0	0	0	0	0
	BIND	BIOGRID	DIP	HPRD	INTACT	MINT	MPACT	MPPI	OPHID	CORUM
	(20125)	(8457)	(0)	(0)	(13240)	(3410)	(0)	(43)	(2301)	(0)

Summary of mapping interaction records to RIGs (Table 5)

Source	Total records	Protein-only interactors	PPI Assigned to RIGID	Unique RIGIDs
bind	193648	93957	91179(97.0433%)	62831(68.9095%)
grid	229399	229399	229101(99.8701%)	155527(67.8858%)
intact	127880	127179	126757(99.6682%)	110545(87.2102%)
mint	104847	104847	103520(98.7343%)	73729(71.2220%)
ophid	73257	73257	72907(99.5222%)	47303(64.8813%)
MPPI	1814	1814	1685(92.8886%)	825(48.9614%)
ALL	730845	630453	625149(99.1587%)	450760(72.1044%)

Assignment of protein interactors to ROGs (Table 3)

Source	Protein_Intractors	Assigned	%	Arbitrary	New	Unassigned	Unique proteins
bind	285482	273644	95.8533	0	7742	4096	40738
grid	28943	18921	65.3733	9923	5	94	27164
intact	97256	93646	96.2881	17	3367	226	41370
mint	80543	77276	95.9438	6	2780	481	28043
MPPI	3628	3456	95.2591	0	27	145	858
ophid	146423	145362	99.2754	103	699	259	9631
All	642275	612305	95.3338	10049	14620	5301	79389

ROG summary

Decimal_score	Binary_flag	String_score	Score_class	Proteins	Percentage	BIND	BioGrid	DIP	MINT	HPRD	OPHID	MIIP	MPACT
778	000000001100001010	SVO+	-1	1	0.0002%	0	0	0	0	0	0	0	0
5386	000001010100001010	SVXL+	-1	1	0.0002%	0	0	0	0	0	0	0	0
196625	110000000000010001	PTNQ	-1	1	0.0002%	0	0	0	0	0	0	0	0
130	000000000010000010	SM	1	546	0.0850%	0	546	0	0	0	0	0	0
129	000000000010000001	PM	1	522	0.0813%	473	1	0	0	0	0	32	0
8193	000010000000000001	PI	1	58	0.0090%	0	2	0	0	0	0	0	0
66	000000000001000010	SD	1	2	0.0003%	0	2	0	0	0	0	0	0
65	000000000001000001	PD	1	9522	1.4825%	8086	1417	0	19	0	0	0	0
8194	000010000000000010	SI	1	12395	1.9299%	12336	59	0	0	0	0	0	0
1	000000000000000001	P	1	533873	83.1222%	232690	7275	0	74838	0	125715	3023	0
10	000000000000001010	SV	1	7	0.0011%	0	0	0	0	0	0	0	0
2	000000000000000010	S	1	7985	1.2432%	0	7523	0	242	0	0	0	0
774	000000001100000110	SUO+	2	1	0.0002%	0	0	0	0	0	0	0	0
773	000000001100000101	PUO+	2	7	0.0011%	0	0	0	1	0	0	0	0
5	000000000000000101	PU	2	20497	3.1913%	0	0	0	426	0	19520	320	0
6	000000000000000110	SU	2	572	0.0891%	0	559	0	5	0	0	0	0
16386	000100000000000010	SE	2	5402	0.8411%	5402	0	0	0	0	0	0	0
16385	000100000000000001	PE	2	211	0.0329%	0	0	0	0	0	0	0	0
8210	000010000000010010	STI	3	903	0.1406%	855	48	0	0	0	0	0	0
8209	000010000000010001	PTI	3	13	0.0020%	0	0	0	0	0	0	0	0
17	000000000000010001	PT	3	16259	2.5315%	11871	0	0	1739	0	122	46	0
146	000000000010010010	STM	3	1	0.0002%	0	1	0	0	0	0	0	0
18	000000000000010010	ST	3	1490	0.2320%	0	1487	0	0	0	0	0	0
145	000000000010010001	PTM	3	168	0.0262%	132	0	0	0	0	0	35	0
81	000000000001010001	PTD	3	1484	0.2311%	1484	0	0	0	0	0	0	0
26	000000000000011010	SVT	3	1	0.0002%	0	0	0	0	0	0	0	0
789	000000001100010101	PUTO+	4	14	0.0022%	0	0	0	0	0	0	0	0
16402	000100000000010010	STE	4	315	0.0490%	315	0	0	0	0	0	0	0
16401	000100000000010001	PTE	4	3	0.0005%	0	0	0	0	0	0	0	0
22	000000000000010110	SUT	4	1	0.0002%	0	1	0	0	0	0	0	0
4482	000001000110000010	SML+	5	394	0.0613%	0	394	0	0	0	0	0	0
131073	100000000000000001	PQ	5	2	0.0003%	0	0	0	0	0	0	0	0
131077	100000000000000101	PUQ	5	1	0.0002%	0	0	0	0	0	0	0	0
131089	100000000000010001	PTQ	5	38	0.0059%	0	0	0	0	0	0	0	0
4357	000001000100000101	PUL+	5	84	0.0131%	0	0	0	0	0	84	0	0
4373	000001000100010101	PUTL+	5	9	0.0014%	0	0	0	1	0	0	0	0
5381	000001010100000101	PUXL+	5	32	0.0050%	0	0	0	5	0	19	0	0
21	000000000000010101	PUT	5	11	0.0017%	0	0	0	6	0	5	0	0
12546	000011000100000010	SLI+	5	6562	1.0217%	0	6562	0	0	0	0	0	0
4354	000001000100000010	SL+	5	2967	0.4620%	0	2967	0	0	0	0	0	0
86274	010101000100000010	SLEN+	6	2	0.0003%	0	2	0	0	0	0	0	0
81938	010100000000010010	STEN	6	24	0.0037%	24	0	0	0	0	0	0	0
81922	010100000000000010	SEN	6	5374	0.8367%	5371	3	0	0	0	0	0	0
81921	010100000000000001	PEN	6	2746	0.4275%	2343	0	0	53	0	98	25	0
65601	010000000001000001	PDN	6	1	0.0002%	1	0	0	0	0	0	0	0
65553	010000000000010001	PTN	6	10	0.0016%	0	0	0	0	0	0	0	0
65537	010000000000000001	PN	6	6457	1.0053%	0	0	0	2727	0	601	0	0
81937	010100000000010001	PTEN	6	5	0.0008%	3	0	0	0	0	0	2	0

Scores (Table 2)

Character	Description of feature (when the value is 1)	Frequency
D	The source database (D) listed in the interaction record is different than what is expected for the given accession for the protein. In specific cases, this difference is tolerated and the assignment is made.	11009(1.7283%)
E	The protein reference was a retired NCBI Identifier. NCBI's eUtils (E) were used to retrieve the current accession and/or sequence.	14082(2.2108%)
G	The interaction record's reference for the protein was an EntrezGene (G) identifier. The corresponding products of the gene were used to make the assignment.	0(0.0%)
L	More than one possible assignment is possible (see + above). The assignment with the largest (L) SEGUID is arbitrarily chosen (see Methods)	10051(1.5779%)
M	The protein reference listed by the interaction record was a typographical modification (M) of a known accession. In specific cases, this variation istolerated and the assignment is made.	1631(0.2561%)
+	More than one possible assignment is possible (+). This case may arise in one of three ways. 1) The reference supplied by the interaction record requires updating but more than one possibility exists. For example, Q7XJL8 was found to be a secondary accession in three separate UniProt records (Q3EBZ2, Q6DR20, and Q8GWA9). 2) The secondary references supplied by the interaction record point to more than one unique protein sequence. 3) An EntrezGene identifier is provided in the interaction record as a protein reference. This identifier points to more than one protein product. An attempt is made to resolve this ambiguity as indicated by ROG score features O, X or L (see below).	10074(1.5815%)
N	The protein reference, taxonomy identifier and sequence for the protein as provided in the interaction record are used to make a new entry in the SEGUID table. The protein interactor is assigned the newly (N) generated ROG identifier.	14620(2.2952%)
O	More than one possible assignment is possible (see + above). The assignment chosen has a SEGUID that is identical to the SEGUID of the original (O) sequence provided in the interaction record.	23(0.0036%)
I	The protein reference used was an NCBI GenInfo Identifier (I).	19931(3.129%)
U	The protein reference listed in the interaction record and used to make the assignment was a secondary UniProt accession and was updated (U) to a primary UniProt accession in order to make the assignment.	21229(3.3328%)
T	The taxonomy (T) identifier for the protein (as supplied by the interaction record) differed from what was found in the protein sequence record. This discrepancy was tolerated and the assignment was made	20750(3.2576%)
V	The protein reference listed by the interaction record contained version (V) information that was ignored. For example, RefSeq accession.version NP_012420.1 was listed but treated as RefSeq accession NP_012420.	10(0.0016%)
Q	The protein reference used to make the assignment was of the type 'see-also'. See PSI-MI Path: entrySet/entry/interactorList/interactor/xref/primaryRef/refType = 'see-also'.	42(0.0066%)
P	The interaction record's primary (P) reference for the protein was used to make the assignment	592028(92.9438%)
S	One of the interaction record's secondary (S) references for the protein was used to make the assignment	44946(7.0562%)
X	More than one possible assignment is possible (see + above). The assignment chosen has the same taxonomy (X) identifier as listed in the interaction record	33(0.0052%)